Characteristics:
Appearance: White to pale cream powder
Matrix: Copolymer of methacrylic acid and divinyl benzene
Functional Group: Carboxylic acid
Ionic form as supplied: Potassium
Solubility: Insoluble in water and in common solvents
Specifications:
READY TO USE GRADES polacrilin potassium USP/NF:
Ready to use grades are drug specific taste masking system enables formulator a single step process. It contains taste masking polymer, sweetener, suspending agent, preservatives, color, flavor and other desire excipients. It is available in various flavors like Banana, Pineapple, Cherry, Strawberry, Peppermint flavor etc. and also as per customer’s requirement.
As Disintegrating agent: Methron (Polacrilin Potassium) has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without the formation of lumps and thus acts as an effective tablet super disintegrant. It can be used during mixing and/or at lubrication stage.
Ex.: Immediate release tablets, Herbal tablets, Mouth dissolving tablets etc.
As Dissolution Improver: Polacrilin Potassium breaks the tablets into very smaller particles, thus it increases the effective surface area for the absorption of the active substances and thus it increases the dissolution and bioavailability of the active substances.
Examples for Polacrilin Potassium: Cefuroxime Axetil, Cefpodoxime Proxetil, Atorvastatin Calcium, Telmisartan, Glimepiride, Gliclazide, Ondansetron etc.
Examples for Polacrilin Potassium: Ciprofloxacin HCl, Levofloxacin HCl, Fexofenadine HCl etc.
ADVANTAGES:
* Remarkable-swelling tendency on wetting, causing rapid disintegration.
* No lump formation on disintegration.
* Compatible with commonly used therapeutic agents and excipients.
* Works equally efficiently in hydrophilic and hydrophobic formulations.
* Gives good mechanical strength to the tablet.
* Facilitating easy packing and transportation.
* Does not dissolve or have an adhesive tendency as in case of gums.
* Does not stick to punches and dyes.
* Rapid disintegrating agent
* Elimination of lump formation
* Compatible with all therapeutic agents and excipients
* Imparts excellent strength to the tablets
* Elimination of the sticking problems to the dies and punch
* Improves bioavailability of the drug
* Uniformly mix with low dose tablets blend or formulations
* Smooth surface after storage
* Provide smooth cream-like mouth feel, so more suitable for ODT
* Suitable for both direct compression and wet granulation methods
* Cost effective
* White in color
* Directly compressible grade
* Dissolution improver
* Effective at very low concentration (0.5 to 4.0%).
Toxicity
Methron is high molecular weight polymer, so doesn’t get absorbed by body tissue and is safe for human consumption. It has no physiological action at recommended dosage and it is non toxic.
Storage
Store in tightly closed container. Keep away from moisture. If moisture is absorbed then dry at 90℃ to 100℃ to remove moisture content and make it below 10%.
Shelf Life
Five years from the date of manufacturing in intact condition.
Packing
10 kg and 25 kg, net in laminated fiber drum with polyethylene liner.
